010081
06-12-2007, 10:47 AM
Patients with the highest blood level of 25-hydroxyvitamin D had the lowest risk of breast cancer ststes the Journal of Steroid Biochemistry and Molecular Biology,jan 30,07;based on two studies the Havard Nurses Health Study and the St.George's Hospital Study.
Dr.Garland and his team divided more than 1700 records in the studies into 5 groups from the lowest blood level of 25-hydroxyvitamin D (<13 ng/ml ) to the highest (approx. 52 ng/ml).These data also included whether the patient had developed cancer.
The investigation found the patients with serum 25-hydroxyvitamin D of approximately 52 ng/ml had a 50% lower risk of breast cancer than those with serum measurinf less than 13 ng/ml.This level correspond to a vitamin D intake of 4000 IU per day,which exceeds the National Academy of Sciences upper limit of 2000 IU per day."Leading reserchers are building a case to have this level increased,"Dr.Garland informed,"but in the mean time,we are recommending a daily intake of 2000 IU."
The study group also suggested for an additional 10 to 15 minutes of daily sun exposure when appropriate-an amount estimated to be equivalent to an oral intake of 3000 IU of vitamin D3.
How vitamin D fights cancer:
Vitamin D appears to help to inhibit development of cancer in two ways:
Vitamin D inhibits inappropriate cell division and enhances the anti-cancer action of immune system chemicals(eg,tumor necrosis factor,interleukins 1 and 6 )
The active hormonal version of vitamin D is produced from circulating vitamin D by cells in organ prone to cancer ( colon,breast,prostate and skin ),which means that it is able to influence the initiation and growth of cancer in these organs.
And vitamin D also helps once a cancer gets to toehold:
Vitamin D reduces blood vessel formation around tumors and inhibits metastasis (action that becomes important once cancer develops.)
Vitamins D enhances the efficacy of chemotherapy drugs (eg,Doxorubicin)
Dr.Garland and his team divided more than 1700 records in the studies into 5 groups from the lowest blood level of 25-hydroxyvitamin D (<13 ng/ml ) to the highest (approx. 52 ng/ml).These data also included whether the patient had developed cancer.
The investigation found the patients with serum 25-hydroxyvitamin D of approximately 52 ng/ml had a 50% lower risk of breast cancer than those with serum measurinf less than 13 ng/ml.This level correspond to a vitamin D intake of 4000 IU per day,which exceeds the National Academy of Sciences upper limit of 2000 IU per day."Leading reserchers are building a case to have this level increased,"Dr.Garland informed,"but in the mean time,we are recommending a daily intake of 2000 IU."
The study group also suggested for an additional 10 to 15 minutes of daily sun exposure when appropriate-an amount estimated to be equivalent to an oral intake of 3000 IU of vitamin D3.
How vitamin D fights cancer:
Vitamin D appears to help to inhibit development of cancer in two ways:
Vitamin D inhibits inappropriate cell division and enhances the anti-cancer action of immune system chemicals(eg,tumor necrosis factor,interleukins 1 and 6 )
The active hormonal version of vitamin D is produced from circulating vitamin D by cells in organ prone to cancer ( colon,breast,prostate and skin ),which means that it is able to influence the initiation and growth of cancer in these organs.
And vitamin D also helps once a cancer gets to toehold:
Vitamin D reduces blood vessel formation around tumors and inhibits metastasis (action that becomes important once cancer develops.)
Vitamins D enhances the efficacy of chemotherapy drugs (eg,Doxorubicin)